Review Of PlaqueOff For Cats

PlaqueOff has been the best thing I have been able to buy over-the-counter for my cat Lily. I discovered PlaqueOff while searching through for anything that might help her stomatitis symptoms.

When I wrote this review in early 2013 I had been giving PlaqueOff to Lily for almost four months. Two years later Lily has improved so much that her stomatitis seems to be completely controlled and I was able to wean her from the steroid cream she had been on. This product has been truly amazing for her, and I think it may be just as helpful to other cats suffering from the symptoms of stomatitis.

IMPORTANT – Before I continue, though, I want to state now that PlaqueOff should not be given to cats that have hyperthyroidism. I discuss this a bit more below, but I want to make this clear so that cat owners of cats with hyperthyroidism know that this is not a product they should use.

[12/19/2013 Edit – When I first started buying PlaqueOff for Cats, it was sold on Amazon by someone located in England. She sold it for about $12, plus $2 shipping. She has since stopped selling it, and someone else is. The new seller has increased the price horrifically. The last time I checked it was being sold for about $39, with shipping that cost about another $39. That is despicable! My guess is that this person is able to sell it for that price because there is no other competition. I know that the regular PlaqueOff product is identical, except that it does not contain brewer’s yeast for flavoring. I bought a bottle before running out of the cat formulation, hoping that Lily would eat that instead. Fortunately, she is fine with it. I suggest you start with the much less expensive PlaqueOff product. If your cat refuses to eat it, then buy the more expensive cat version or add Brewer’s yeast to it.]

What Is PlaqueOff?

PlaqueOff is a powder. The ingredients listed on the package are:

  • Seaweed meal (specially selected Ascophyllum nodosum D1070)
  • Brewer’s yeast

There is another version of this product meant for either dogs or cats that contains only seaweed, but some cats apparently didn’t like the flavor. Brewer’s yeast was added to the cat version to make it palatable to finicky felines. Brewer’s yeast has a flavor most cats love and it is safe for them to eat.

How Does PlaqueOff Work?

The research that I did on this product states that it works systemically. It is believed that the seaweed somehow prevents plaque from sticking to teeth and gums, therefore minimizing a variety of mouth ailments such as plaque, tartar, and bad breath. This product is not meant specifically for stomatitis, but it is helpful because it greatly diminishes plaque, which is most often the cause of stomatitis symptoms.

How Do You Give PlaqueOff To A Cat?

This is very easy. The container comes with a measuring spoon. All you need to do is sprinkle a spoonful of the powder onto either wet or dry food so your cat will ingest the powder with her food.

To be honest, I am not sure if cats will eat this over dry food. My thinking is that the powder will fall to the bottom of the bowl and not get eaten. Therefore, I give this to Lily by mixing it with a small amount of wet food that has been diluted with water.

Are There Any Side Effects Of PlaqueOff?

According to the manufacturer, the answer to this question is, “No.” However, they state that this product should not be given to a cat that suffers from hyperthyroidism. Check with your vet before giving this to your cat if you are unsure if your cat has hyperthyroidism. Otherwise, it is perfectly safe to give this supplement to your cat.

How Long Will One Container Last?

I do not yet know the answer to this. I give Lily one scoop per day, and I started giving it to her almost four months ago. The container says that it should last for about six months, but I have quite a bit left. My guess is that one container will last us between nine months and one year.

04/28/2015 Update: The container that I originally bought, when I was giving it just to Lily, was the 180gm bottle. This size lasted at least six months when given daily to one cat. Now I buy the larger 420gm container and give it to all five of my cats each day. The 420gm container lasts me about one year when given to my five cats.

How Long Will It Take Before You See Improvement In Your Cat’s Stomatitis Symptoms?

According to the manufacturer, it can take between three and eight weeks before you see improvement. Keep in mind this timeframe is for non-stomatitis symptoms. I can tell you that I noticed improvement within four weeks, and even more improvement at eight weeks.

What Is The Difference Between The Two Types of PlaqueOff?

ProDen makes two versions of PlaqueOff: PlaqueOff Animal (for cats and dogs) and PlaqueOff Cat (specifically for cats). The ONLY difference is that the cat version has Brewer’s yeast added to it to make it a bit more tasty for cats. Cats are notoriously finicky but they love Brewer’s yeast, which is why it is added to the cat version.

Again, there is no difference at all other than the Brewer’s yeast. I am stressing this because you might want to start with the Animal version, which is much less expensive to buy on Amazon than the Cat version. If you cat turns up her nose at the Cat version then you can add a bit of Brewer’s yeast to flavor it. Or, you can give it to your cat the way I do by mixing it with a bit of water and wet food. A little further down this page you will find a video showing you exactly how I give PlaqueOff to Lily.

Where Can You Buy PlaqueOff?

PlaqueOff is made by a company in the United Kingdom. I live in the United States and my vet had never heard of PlaqueOff prior to when I showed it to her (she looked at the ingredients and verified that there is nothing harmful in it), which tells me that it is not a well-known product here in the US. This is not a product that you can find locally here in the states, so if you also are a resident of the US I recommend that you buy from

 which is where I buy it from.

It comes in three sizes: 60gm, 180gm, and 420gm. I have both the 180gm and 420gm containers. I originally bought the smaller 180gm container but then I discovered that there is a larger container and that is what I buy now. The larger container is much more cost effective, especially since I now give PlaqueOff to all five of my cats. I kept the smaller container and I fill it from the larger one. I’ve never tried the 60gm size but the medium and large sizes both include dosage spoons so you don’t have to wonder how much to give your cat.


As of this writing there is only one seller of this product on Amazon, and the seller is located in the United Kingdom. Do not let this scare you because the cost of shipping is incredibly reasonable. However, this means it may take a few weeks for your order to get to you. [See my 12/19/2013 edit near the top of this page about PlaqueOff sellers on Amazon.]

If you purchase PlaqueOff and it helps your cat as much as it does mine, be sure to order a new bottle about a month before you think you will run out so that your cat does not have to go without while you wait for the new batch to arrive.

If you are a resident of the United Kingdom then the easiest way to place an order is directly through the manufacturer ProDen. You can either call them at 0800 032 9099 or visit their website at

Pictures Of Lily’s Improvement After Taking PlaqueOff

As I stated above, I saw improvement in Lily’s symptoms of stomatitis after four weeks, and there was additional improvement after eight weeks. You can see for yourself how much better her stomatitis looks because of the PlaqueOff.

Before Starting PlaqueOff

Unfortunately I do not have a “Before” photo to show what her mouth looked like before I started treating her with PlaqueOff. My vet and I tried to get a photo but it hurt Lily too much to have her mouth held open so we couldn’t get a photo. I remember it well, though. The back of her throat was fire-engine red, and it looked meaty, like raw hamburger.

Four and Eight Weeks After Starting PlaqueOff:

The first photo below looks painful, but it looks much better than how her mouth looked before she started PlaqueOff (I deeply regret not taking a “before” picture). Lily’s stomatitis in the “After Four Weeks” picture is bright red, the back of her throat is very inflamed, and her gums where her teeth used to be is also bright red.

In the “After Eight Weeks” picture the color is a lighter shade of red than four weeks earlier and the inflammation in the back of her throat started to calm down. The difference is striking!

Side-By-Side Comparison

Two Years After Starting PlaqueOff:

04/28/2015 Update: I just realized that I did not take another picture of Lily’s mouth and it is time for me to correct that. Here is how Lily’s mouth looks today, about two years after she started taking PlaqueOff. As you can see, it looks even better than the “eight week” picture above.

Lily’s throat still has some pinkness, but it is no longer red or inflamed, and the redness on her gums where her teeth used to be is completely gone. Her mouth can now be touched and she doesn’t show signs of any pain at all.

Lily's mouth two years after starting PlaqueOff

How I Give PlaqueOff to Lily

Here is a video I made that shows how I give both PlaqueOff and Lysine to Lily.

My Conclusion About PlaqueOff

It should come as no surprise for you to learn that I wholeheartedly recommend PlaqueOff Cat. This product has made a life-changing difference for my cat Lily. I can see that she feels better because she is playful again, and she almost never drools now that she is taking this supplement.

Regarding Lily’s drooling, I didn’t keep track of how often she drooled before she started this, but I have an idea because I give her a pain medicine called Buprenex when she drools. Before starting Plaque Off I was giving her a dose of Buprenex about once a week. Now, I give it to her maybe once a month, possibly even less often than that. That’s huge.

10/07/2013 Update: It has now been five months since I wrote this review. Lily has not needed the pain medicine Buprenex in at least six months. I credit PlaqueOff for her incredible improvement!

The bottom line for me is that PlaqueOff truly is a must-have supplement that has improved Lily’s quality of life!


Review Of PlaqueOff For Cats — 76 Comments

  1. Unfortunately, my female cat, Buttons, was diagnosed 2 years ago with Stomatitis. I was heartbroken! Now I found carries Plaqueoff. I began putting it on her food and I noticed symptoms were reduced quite fast. Their service is great and cost me about $35.00 for 2 containers. I would love to see a cure for this very painful ailment in cats, but since it is an autoimmune disease, that is doubtful.

  2. Christina,

    Given that PlaqueOff is meant for plaque on teeth I’m sure it will be helpful to your beagle. As for your sister’s cat, it should be okay, but you might recommend that she check with her vet before starting it, just to be sure. The only potential problem that I know of has to do with the thyroid, not the kidney. It shouldn’t be given to a cat with hyperthyroidism because it will make the condition worse.


  3. I love your article about Lilly and plaque off. My dog has much plaque on her teeth and no amount of brushing seems to help, so I found your article really helpful. I shall buy plaque off for Kim my Beagle and see how we go. I will also tell my sister who has a cat too. I hope this is safe for my sister’s cat as she has low kidney function and was due to have her teeth cleaned the coming week. Your cats are beautiful

  4. Anna,

    Thank you for sharing what worked for your cat!

    “Stabilizing” is a good word. We got Lily stabilized. In Lily’s case, her stomatitis wasn’t completely gone, but we got it under control to the point that the pain seemed to be gone. I’m very happy to hear that you were able to stabilize your cat and, hopefully, the stomatitis stays at bay for the rest of his life.


  5. I have had success stabilizing my cat suffering from stomatitis without having to give him steroids or extracting his teeth. In addition to giving him PlaqueOff for Cats, I am giving him:

    1-TDC capsules:

    Colostrum from Sovereign Laboraties:

    My cat also had a dental a few weeks ago, which was about a year after the diagnosis. I believe the dental has helped him benefit from the supplements.

  6. Susan,

    Yes, your vet is right. I was given tiny little fingertip gloves to use when I gave this to Lily. You can reuse them, since you probably won’t have enough for every day. Or, you can buy gloves in bulk, such as at Sam’s Club.


  7. I also have a cat Lilly who has stomotitis. One thing our vet told us is to be sure to wear a plastic glove when putting the prednizone on or it can obsorb into your skin. I am just starting her on lysine and her brother too. I will get PlaqueOff as well. Thanks

  8. Les,

    Yes, it is possible to brush a cat’s teeth, though I’ve never done it myself. Many people say that it does a great job of preventing mouth problems. I’m sure there are videos on YouTube that can help show you how. Good luck!


  9. Hello Rochelle: I have been rescuing stray cats for a decade. I currently have nine felines, one a 5yr male, born here, w stomatitis & drooling. My cats enjoy my pet door (exit…stage left) in nice weather. Pickles got antibiotic & cortisone shots, temporary boost only. I need to learn how to brush my cats’ teeth, is that possible? Sounds like w prevalence of stomatitis, oral hygiene’s important. Brewer’s Yeast has sulphur & tastes bitter. Tastier nutritional yeasts exist, I’ve tried them myself.
    Regarding Iodine toxicity. Food-forms & AA chelates would just get excreted in excess. Lugol’s solution, saturated potassium iodide 10%, while fine externally could bio-accumulate.
    I love Sea Vegetables. I used to purchase kelp, alaria, dulse, Irish moss & Laver (Nori 30% protein) cheap by the box from Maine Seaweed Company, POBox 57, Steuben, Maine 04680. Google Larch Hansen. They collect seaweed spring & fall, sun-drying the harvest on the beach. They harvest responsibly in unpolluted waters w oiled(not painted) wooden boats. Seaweed’s loaded w minerals, b/c they grow on rocks- the only source of minerals…only way to alkalinize body or mouth tissues.
    I bought Ascophyllum Nodosum (rock grains) in $3 cannisters & kelp $7lb back then, but I’m sure price has gone up. Loved cooking w seaweed & the Ascophyllum tasted like fresh clam chowder. I could smell the sea upon raising the lid. I cooked w beans, purple thai rice & lotsa garlic, cooling it w half-doz eggs & butter. I gotta start eating that way again, makes me feel like Rin Tin Tin. Seaweed may be great feline food supplement. Infections need alkalinizing. Les

  10. Dear Rochelle,
    I rescued a feral kitty who happened to have stomatitis. I read your wonderful site, which I know save so many kitty lives. Milky Mustashee, had a cleaning and eight teeth removed. When the vet gives him an antibiotic shot and an anti inflamitory shot it could last him for weeks before he shows signs of eating discomfort again. I rather recently put him on Proden PlaquOff for cats and dogs, L-Lysine, Coenzyme Q10, and Dr. jones Ultimate Feline Formula. The L-lysine is a gel that I can mix other supplements in and put on his paws to lick off so that I do not have to alter the taste of his food, which he sometimes does not like. He also gets grain free kibble and moist cat food, the turkey food you give Lilly. I have also started him on a raw food diet of turkey.
    Are you still giving Lilly a Prednisone cream. Is that rubbed on her ear? I saw by one of your updates a few years back that she was able to go without it by the time of the update, for six months. I see that you also give Lilly L-Lysine 2x daily and Proden PlaqOff 1x daily so I am following that. Dos Lilly take any antibiotics and is she still off Bupronex?

    Thank you for all you do!!!!
    Hugs, Lehua & Milky Mustashee

  11. Bless you and Lilly for all you have done!!! Your efforts have saved Lilly and so many other kitties and their human companions!!! God, bless you and Lilly!!!!

  12. Based on a friend’s experience with the company Vitality Science Holistic Pet Remedies, I am considering purchasing this product for my cat, who has stomatitis:

    I’ve been giving my cat PlaqueOff and Lysine for about three weeks, and although my vet has not seen improvement, I’d like to give the PlaqueOff and Lysine a full 8 weeks before I do anything else.

    The next thing I would consider is the “Advanced Immune Restoration Cat Cancer Support” product above, as the company tells me that since stomatitis is an immune related issue, and the Advanced Immune product raises immune competence, it is an appropriate product for my cat.

    Has anyone else used this product for their cut with stomatitis?

    Thanks for any feedback.


  13. RaeNelle,

    Poor Greta has had a lot to overcome for such a young age!

    Mammary hyperplasia is something I’ve never heard of but hopefully someone else can comment on it.

    Lily was very young (about 1 1/2 years old) when she had her teeth pulled. I can say with total honesty that if I had to do it all over again I would have pulled her teeth sooner. It has been over two years since her teeth were removed. She’s still on Lysine and PlaqueOff, which I will keep her on for life (unless I have to stop the PlaqueOff if she develops a thyroid problem), and you’d never know to look at her today what she went through with stomatitis.

    She still has a small amount of inflammation in the back of her throat, but it doesn’t seem to bother her at all. She has a very healthy appetite and has no problems eating dry food (Iams, which is a very small kibble). She runs, plays, and is very loving. Unlike when the stomatitis was full blown, she now uses her mouth to play with her toys and loves it when I rub on her face, chin, and mouth.

    Please keep us posted on Greta’s progress.


  14. Kathi,

    I apologize for not seeing this sooner.

    If your cat’s teeth are already bad then I don’t think the Lysine and PlaqueOff will help. The PlaqueOff is meant to keep clean teeth from getting bad plaque on them and I wouldn’t trust that it would work on teeth that are already covered in plaque.


  15. Elizabeth,

    I’m fairly certain that the spoon is about 1/8 tsp. I hope that helps.


  16. I have a 10 month old kitten, Greta, with severe stomatitis. I started noticing she was having issues after what I thought was a bad bought of teething and very bad breath. After antibiotic treatment and a change in vets I was told something else may need to be done for her. She was spay a few months back and the surgeon cringed when he looked in her mouth (and actually called in others to look at them as a learning experience). Besides the teething Greta seemed to be doing fine and I decided to wait a while to do anything drastic. Also the vet said there was still a change she could have juvenile stomatitis and would outgrow it. The past few weeks I have noticed Greta cutting back on how fast she eats (she is usually a chow hound) and being more vocal than usual. She has also been very ginger when playing with her toys (she stopped carrying them around) and will sometimes rub her face of things as to massage her poor gums. I stumbled across this blog and ordered PlaqueOff as a last resort. She has been on it for about a week and a half when I started noticing lumps forming around her nipples. I brought her to the vet and they said it was mammary tissue development (mammary hyperplasia) and since she was spayed a few months back they suspected it was from excess hormones she may be consuming. Note: She did have some mammary hyperplasia before her spay that went away after the procedure. My cat has been on Vetriscience Vetri-DMG and more recently PlaqueOff for Cats. (Also L-Lysine and probiotics which the vet said should not be the issue) The vet also suggested it could be a thyroid problem (although her blood work shows no issues) and could be caused by plant based or other supplements. I am aware that iodine is an ingredient in PlaqueOff and this could be the problem if the lumps were triggered by her thyroid, but we are still unsure. As of now my cat has stopped all supplements to see if there is any improvement. Greta is schedules for a gum tissue biopsy along with x-rays and removing her top and bottom incisors (they are loose and already coming out) next week. The vet said they will decide how to proceed after the biopsy results whether it be steroids, antibiotics or extractions (he told me he was leaning toward the extractions with the severity of her case.) I am wondering if anyone else has had mammary hyperplasia occur in their spayed cat and what else could be causing it. Also has anyone else had to have extractions in their cat at such a young age? I just feel awful doing such a drastic procedure so young but feel it may be best for her. Not sure I would want her to be on steroids for a long period of time due to the long term side effects.

    Sincerely a worried cat mom.

    Other info on Greta:
    -Eats Purevita chicken and peas
    -Lately eating Blue Buffalo Wilderness Tasty Toppers Wild Cuts chicken for treat and when teeth seem to be hurting her
    -Possible Feline Infectious Peritonitis in her litter (have had to euthanize 2 of the 4 kittens with what vets suspected to be FIP) but Greta and her surviving sister have been otherwise healthy
    -Went through her spay and anesthesia very well (was worried because one of her litter mates became ill after anesthesia procedure and had to be euthanized)
    -Greta’s mom (farm cat) has lived to a ripe old age (at least 10yrs) I recently looked in her moms mouth and saw that her teeth have rotted out and there are few left, guessing it is hereditary.
    -Greta is on L-Lysine to prevent eye irritation and goop (had a severe eye infection as a kitten) and has been on probiotics since her fight with giardia (lasted about 6 months) She was on forti-flora from the vet and is now on Gentle Digest

  17. Our vet thought that our 3 yr old rescue cat had stomatitis. She has had two treatments of antibiotics and it helped. She has lost some teeth and the vet suggested having her teeth cleaned. Since this treatment is expensive, I was wondering if it was worth it or whether I should just start her on the Plaque Off and L-Lysline. She drools but does not appear to have blood in her drool and does not appear to be in pain.

  18. Hi! I did a search for the ingredient of PlaqueOff (ascophyllum nodosum) and found I could simply purchase the powdered seaweed from an online vitamin and health food store. It is MUCH cheaper that way. The only thing I don’t know is how large the measuring scoop is. Can you compare it to a standard measuring spoon and tell me what it is?

  19. Mona,

    One of our cats is currently dealing with tooth resorption so we know first hand how difficult that can be for a cat. But perhaps the good news is that your cat doesn’t have stomatitis. Hopefully your kitty will be okay now that his teeth have been removed.


  20. Thanks Rochelle,

    It’s great that Lily is off the steroid cream. As it turned out our cat doesn’t have stomatitis, but has feline tooth resorption. He had four canines removed and the plaqueoff might have not caused a side effect. We had no idea since he didn’t show any signs until one day a canine was gone. I hope all stays well with Lily and she won’t have any flare ups. Thanks for replying and all the best.

  21. Caitlin,

    There is a warning on the label for PlaqueOff that says it should not be given to cats that have hyperthyroidism because of its iodine content. I don’t know if giving too much PlaqueOff would cause a thyroid problem, but that could be possible. I hope this helps.


  22. Mona,

    I’m sorry to hear that your cat seems to be experiencing side effects from the PlaqueOff.

    You asked a good question regarding how I know that the PlaqueOff is helping Lily if she is also getting Prednisolone. Before Lily started taking PlaqueOff we gave her Lysine and Prednisolone, along with a pain medicine as needed. Then I started her on PlaqueOff, and about a year after she started it I was able to wean her off the Prednisolone. Lily hasn’t had the steroid cream in over a year and she continues to do great. She currently takes just the Lysine and PlaqueOff. It is possible that she no longer needs either of these items but I won’t stop giving them to her because I don’t want to risk a flare-up of the stomatitis.

    Have you talked to your vet about the drooling or bad breath? It might not be the PlaqueOff causing it. I hope you are able to find relief for your cat.


  23. We gave our cat the plaqueoff for several week, just around nine or so. He started drooling excessively and he has never done this before, no stomatitis either, just bad breath. I found your side and was first confident that it would work, but since reading more I am not so sure about it anymore. I watched the video of giving your cat the supplements, but how can you be sure that the plaqueoff is helping since you are also treating her with prednisone? I tried to find any reviews about side effects but it seems that they have either not been out there or not enough people treat their cats with it. Also I found out that the plaqueoff works systemic, from the inside out and that there can be plateauing as well. I just want to share the experience our cat had and it is not a good one.

  24. I live in the Middle East and rescue a lot of cats. Many have dental issues and I’m very interested in PlaqueOff. I’ve seen lots of reviews and they are mostly good, but I’ve seen a few comments that people’s pets have developed thyroid problems because of the high iodine content. I know it’s a fact that too much iodine affects thyroids–even in people–so I’m wondering if this is something to be worried about. Maybe these people were also feeding their pets food with too much iodine? Or they had an underlying thyroid problem that was unknown before taking PlaqueOff?

    Thanks for this website btw. I am anticipating coming across street cats with stomatisis and now I know how to treat it 🙂

  25. Thank you for all the info on plaqueoff, I will be buying it today! I do feel compelled to tell you what I have done extensive reading on it diets. Dry food is the worst thing you could feed a cat. Dry food will literally dehydrate a cat. Raw food it the best because it contains the the moisture your cat needs. Their natural diet is something like 80%water. If raw is something that you dont want to feed dehydrated raw is another option. If raw not raw than strictly canned is ok. You can actually add alittle water to canned to make it more hydrating. I read that the worst canned food is better than the best dry food. I have spent hours and hours reading about this and I am really pleased with the change it has made it my cat as well as my moms. My cat had very bad gas and also when he would defecate the smell was horrific. Since the diet change gas is gone and his stool had no smell at all! My mother has a very overweight cat and since the raw diet she has lost weight but more importantly she is so much more active. She used to sleep constantly and now she and her sister explore and play, the change in behavior is amazing! Just wanted to share and thanks again for all the info on Plaqueoff!

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